There is abundant evidence that alterations in key neurotransmitters can both be modified by and contribute to oxidative stress and membrane dysfunction ( Figure 1 ), suggesting a link among oxidative stress, membrane dysfunction, and multi-neurotransmitter pathologies in SZ (Yao and Keshavan, 2011)
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This broad pleiotropy was supported by associations observed in the 23andMe database (Supplementary Table 19)
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